I can see some of the Hydra harness pieces being potentially pretty popular... Sure, it's a once-per-day enchantment with probably a rather short duration... but a lot of fights don't take all that long, and boosted crits, acc, and attack would be nice to have for some folks.
The Hydra doublet set, on the other hand... I don't really get it for the most part. Huge acc and eva boosts, massive -enmity.... for mages. I guess you could wear it while skilling up, but aside from that, I don't see many people going out of their way to pick it up.
As for the Hydra haubert set... again, limited utility I think. Galka PLD might get away with a piece or two, but most PLD don't want -HP, and most DRK don't want +Enmity. As for WAR... not a whole lot of use for MP, and what +Enmity there is I reckon they could get elsewhere if they really wanted it.
The Hydra jupon set is for NPC fanatics, 'nuff said.
The Avatar weapons seem nice enough, I suppose... With the latents probably activating on the proper day and all that.
The majority of the crafted weapons are pretty boring for the most part... Enchantments don't seem to be all that popular with a lot of folks (something about not being able to resell the weapon when you've used it up), the Darksteel Falx does cover a gap in the GS set for DRK but that's about it. The Kaskara might be an alternative for some PLD looking to do more damage per hit than the Durandal while still having some Vit bonuses, but I doubt it's gonna be all that cheap to make.
Crafted armour seems similarly ill-fated, since again it relies on enchantments...
The ancient beastcoin items also don't seem that impressive.
And of course the 72 earring set is teh secks. I just fear what is gonna be required to get them... I wager something on the same order as Divine Might, and you'll probably only be able to get the one.